Endocrine Abstracts

Testosterone therapy has been shown to benefit men with heart failure or coronary artery disease, an activity proposed to be mediated via its vasodilatory efficacy. Testosterone has been demonstrated to dilate human coronary arteries, but it is unknown whether testosterone has a similar action in human pulmonary or systemic vessels.Male patients were recruited from cardiothoracic (n = 14, age = 68 plus/minus 9) or gastrointestinal (n = 8, age = 70 plus/minus 3) operating l...

Testosterone improves symptoms and exercise capacity in men with heart failure (Pugh et al., Heart, 2003, In Press), and has been demonstrated to lower peripheral vascular resistance in such individuals (Pugh et al., Eur.Heart J. 2003, 24, 909-15), consistent with a systemic vasodilatory activity. The vasodilatory mechanism of testosterone has yet to be investigated in the systemic vasculature. Mesenteric tissue was obtained from male patients (n=14, age=70+2), undergoing gast...

Testosterone reduces myocardial ischaemia in men with coronary artery disease, and improves symptoms and exercise capacity in men with heart failure, effects proposed to be due to testosterone-induced coronary, systemic and pulmonary vasodilatation. Endothelial-independent calcium channel antagonism is proposed as the effector mechanism from in vitro animal studies, but this has yet to be confirmed in humans.In the present study we have investigated the ...